Avocado-derived molecule attacks leukemia at its roots

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A molecule found in avocado has shown promise as a potential drug to treat a form of leukemia

Brimming with nutrients, antiooxidants and healthy fats, avocado – otherwise known as nature’s butter – carries a multitude of health benefits inside its coarse, leathery skin. But new research is now pointing to what could be its most valuable secret yet. A Canadian scientist has discovered a lipid in avocado that could prove key to battling leukemia by attacking the deadly disease at its core, namely the highly resilient stem cells that drive the disease and make treating it such a difficult task.

Acute myeloid leukemia (AML) is a type of cancer where blood stem cells evolve into abnormal blood cells, rather than the healthy cells the body would normally produce. These then build up in the bone marrow and crowd out the healthy cells, leading to infection and often death.

Professor Paul Spagnuolo from Canada’s University of Waterloo believes that the disease can be best combated at its core. He managed to identify a compound in avocado, called Avocatin B, which is precise in its targeting of the leukemia stem cells, and can be applied without causing peripheral damage to the surrounding cells.

“The stem cell is really the cell that drives the disease,” says Spagnuolo. “The stem cell is largely responsible for the disease developing and it’s the reason why so many patients with leukemia relapse. We’ve performed many rounds of testing to determine how this new drug works at a molecular level and confirmed that it targets stem cells selectively, leaving healthy cells unharmed.”

Spagnuolo’s work is still in its very early stages and he estimates Avocatin B-inspired leukemia medication to be years away from approval for human use. But he says it could one day greatly improve the quality of life and life expectancy for those suffering from AML. At present he is carrying out experiments with a view to preparing a drug for Phase I clinical trials.

References:http://www.gizmag.com/

Style software gives fashion tips after judging what you wear

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Now even computers are going to be critical of how we look: algorithms are getting into style. New software judges outfits from a photograph and offers tips to make them look even more chic.

“Not everyone has access to an expert,” says Raquel Urtasun, a computer scientist at the University of Toronto, Canada, who developed the software with colleagues in Spain. “You can imagine something like this being used [to style photos for] dating sites and Facebook profiles.”

Fashion is as tough for machines to master Movie Cameraas it is for us, if not more so, largely because it is so subjective. What’s popular now may become passé in a few months, and what works well in a particular culture or setting could be wildly inappropriate in another: think about clothes for date night and clothes for the office. And before a computer works any of this out, it has to be able to correctly identify each item of clothing being worn.

To teach the software about fashion, Urtasun’s team showed it thousands of pictures from Chictopia, a popular style website. The more positive votes left by other users, the more “fashionable” the software perceived the look to be.

It also noted other information about the photo, such as the user’s geographic location, the date they had posted it, the background of the picture, and written descriptions of the clothing.

The resulting software uses this information to categorise outfits and make suggestions based on what was successful for others in similar situations – for example, to add black boots or try something in pastel. The team plans to hone the results further by showing it a more diverse array of photos from other sources.

Urtasun presented the work at the Computer Vision and Pattern Recognition conference in Boston, Massachusetts, earlier this month. Her team plans to improve the software so that it can automate the work of a human stylist.

Alexandra Greenawalt, a personal stylist in New York City, is understandably sceptical about computers muscling in on her patch. Looking good is about more than the latest trends, she says.

When dressing clients, she considers a wide range of factors, including their age, occupation and body shape. An effective algorithm would need to take all that into account, too.

Still, she is curious to watch the technology develop. “What will be interesting to see is if it can predict fashion before it happens or just based on likes in the past,” she says. “I would imagine the teens and 20-year-olds who are very much wanting to be in fashion would find it valuable.”

References:http://www.newscientist.com/

Stretchy ‘Origami Batteries’ Could Power Smart Clothing

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Stretchy batteries inspired by origami could power smartwatches and other wearable electronics, researchers say.

Increasingly, scientists worldwide are developing flexible electronics, such as video displays and solar panels, that could one day make their way into clothing and even human bodies. But one limitation of these devices is the scarcity of equally flexible batteries to power them or store energy they generate.

Although prior research has created bendable batteries, it has proven more challenging to developing ones that are stretchy versions has proven more challenging, researchers said. Now, inventors have created lithium-ion batteries that can stretch to more than 150 percent of their original size, while remaining capable of powering devices. [Top 10 Inventions that Changed the World]

Hanqing Jiang, an associate professor of mechanical and aerospace engineering at Arizona State University in Tempe, came up with the new device after “talking with an origami artist who showed me some famous origami patterns,” he said. One of these patterns, known as the Miura-ori fold, is currently used to fold large maps into small rectangles, and was originally invented to help pack solar panels efficiently on spacecraft.

One problem with using principles of origami to create electronics is that folding often produces uneven surfaces. This can make it difficult to integrate these devices with other electronics, the researchers said.

Instead, Jiang and his colleagues used a variation of origami known as kirigami to create their stretchable batteries. Whereas conventional origami uses only folding to create structures, kirigami uses both folding and cutting. The technique results in structures whose surfaces can stay even after stretching.

“We found a new approach to make stretchable structures using conventional manufacturing approaches,” Jiang said.

The batteries were created using slurries of graphite and lithium cobalt dioxide, which together can store and release electricity. These slurries were coated onto sheets of aluminum foil, and kirigami techniques were then used to fold and cut the sheets into stretchy serpentine shapes.

In experiments, the new batteries could power a Samsung Gear 2 smartwatch even when stretched, the researchers said. The batteries could easily be sewn into a stretchy wristband, which suggests they could be used in flexible wearable devices.

Another research team recently developed a battery that could stretch to 300 percent its original size. In this device, the energy-storing materials were sandwiched between thin sheets of silicon rubber. Jiang said his new battery has an advantage over this previous battery because his is compatible with commercially available manufacturing technologies.

The researchers are now working on creating microscopic origami patterns to combine stretchable batteries with microelectronics. Jiang and his colleagues detailed their findings online June 11 in the journal Scientific Reports.

References:http://www.livescience.com/

World’s Thinnest Light Bulb Created from Graphene

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Graphene, a form of carbon famous for being stronger than steel and more conductive than copper, can add another wonder to the list: making light.

Researchers have developed a light-emitting graphene transistor that works in the same way as the filament in a light bulb.

“We’ve created what is essentially the world’s thinnest light bulb,” study co-author James Hone, a mechanical engineer at Columbia University in New York, said in a Scientists have long wanted to create a teensy “light bulb” to place on a chip, enabling what is called photonic circuits, which run on light rather than electric current. The problem has been one of size and temperature — incandescent filaments must get extremely hot before they can produce visible light. This new graphene device, however, is so efficient and tiny, the resulting technology could offer new ways to make displays or study high-temperature phenomena at small scales, the researchers said. [8 Chemical Elements You’ve Never Heard Of]

Making light

When electric current is passed through an incandescent light bulb’s filament — usually made of tungsten — the filament heats up and glows. Electrons moving through the material knock against electrons in the filament’s atoms, giving them energy. Those electrons return to their former energy levels and emit photons (light) in the process. Crank up the current and voltage enough and the filament in the light bulb hits temperatures of about 5,400 degrees Fahrenheit (3,000 degrees Celsius) for an incandescent. This is one reason light bulbs either have no air in them or are filled with an inert gas like argon: At those temperatures tungsten would react with the oxygen in air and simply burn.

In the new study, the scientists used strips of graphene a few microns across and from 6.5 to 14 microns in length, each spanning a trench of silicon like a bridge. (A micron is one-millionth of a meter, where a hair is about 90 microns thick.) An electrode was attached to the ends of each graphene strip. Just like tungsten, run a current through graphene and the material will light up. But there is an added twist, as graphene conducts heat less efficiently as temperature increases, which means the heat stays in a spot in the center, rather than being relatively evenly distributed as in a tungsten filament.

Myung-Ho Bae, one of the study’s authors, told Live Science trapping the heat in one region makes the lighting more efficient. “The temperature of hot electrons at the center of the graphene is about 3,000 K [4,940 F], while the graphene lattice temperature is still about 2,000 K [3,140 F],” he said. “It results in a hotspot at the center and the light emission region is focused at the center of the graphene, which also makes for better efficiency.” It’s also the reason the electrodes at either end of the graphene don’t melt.

As for why this is the first time light has been made from graphene, study co-leader Yun Daniel Park, a professor of physics at Seoul National University, noted that graphene is usually embedded in or in contact with a substrate.

“Physically suspending graphene essentially eliminates pathways in which heat can escape,” Park said. “If the graphene is on a substrate, much of the heat will be dissipated to the substrate. Before us, other groups had only reported inefficient radiation emission in the infrared from graphene.”

The light emitted from the graphene also reflected off the silicon that each piece was suspended in front of. The reflected light interferes with the emitted light, producing a pattern of emission with peaks at different wavelengths. That opened up another possibility: tuning the light by varying the distance to the silicon.

The principle of the graphene is simple, Park said, but it took a long time to discover.

“It took us nearly five years to figure out the exact mechanism but everything (all the physics) fit. And, the project has turned out to be some kind of a Columbus’ Egg,” he said, referring to a legend in which Christopher Columbus challenged a group of men to make an egg stand on its end; they all failed and Columbus solved the problem by just cracking the shell at one end so that it had a flat bottom.

References:http://www.livescience.com/